Expression of Osteopontin, Interleukin 17 and Interleukin 10 among Rheumatoid Arthritis Sudanese Patients
نویسندگان
چکیده
منابع مشابه
Interleukin-17 gene expression in patients with rheumatoid arthritis.
Interleukin-17 is a proinflammatory cytokine. Recent animal studies have shown that IL-17 plays a role in the initiation and progression of arthritis. However, whether IL-17 has a prominent role in human rheumatoid arthritis (RA) or not remains unclear. Here we investigated the role of IL-17 in patients with RA. cDNA was prepared from knee joint synovial tissues of RA (n = 11) and osteoarthriti...
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Background and aims: Interleukin-10 (IL-10) is an anti-inflammatory cytokine, and its expression is increased in rheumatoid arthritis (RA). A number of novel cytokines have been found recently, which have been designated as the IL-10 family based on their genetic characteristics. These cytokines include IL-19, IL-20, IL-22, IL-24 and IL-26. Information concerning the expression and function of ...
متن کاملInterleukin 10 treatment for rheumatoid arthritis.
Interleukin (IL) 10 looms as a highly promising treatment for rheumatoid arthritis (RA) because of its capacity to inhibit cellular immunity and deactivate macrophages. In RA, activated CD4 T helper cells and macrophages are believed to be the primary driving force behind joint inflammation. Synovial macrophages play a critical part in stimulating synovial inflammation. They produce abundant qu...
متن کاملPathologic finding of increased expression of interleukin-17 in the synovial tissue of rheumatoid arthritis patients.
Rheumatoid arthritis (RA) is a common autoimmune disease of chronic systemic inflammatory disorder that will affect multiple tissues and organs such as skin, heart or lungs; but it principally attacks the joints, producing a nonsuppurative inflammatory and proliferative synovitis that often progresses to major damaging of articular cartilage and joint ankylosis. Although the definite etiology i...
متن کاملInterleukin 17 inhibits progenitor cells in rheumatoid arthritis cartilage
Mesenchymal stem cells are known to exert immunomodulatory effects in inflammatory diseases. Immuneregulatory cells lead to progressive joint destruction in rheumatoid arthritis (RA). Proinflammatory cytokines, such as tumour necrosis factor α (TNF-α) and interleukins (ILs) are the main players. Here, we studied progenitor cells from RA cartilage (RA-CPCs) that are positive for IL-17 receptors ...
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ژورنال
عنوان ژورنال: Archives of Microbiology & Immunology
سال: 2020
ISSN: 2572-9365
DOI: 10.26502/ami.93650052